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These results had been replicated for other hold-out trial sites in our experiments. RCC Classification Accuracy - As soon as the training is completed, the slide-stage accuracy is calculated. For this, the softmax outputs, which are the probability scores representing the diploma of belongingness to each of the RCC subtypes (ccRCC, pRCC, and crRCC), had been averaged over the patches of each WSI. Therefore, the predicted subtype for each WSI may very well be assigned. According to Table I, the proposed hospital-agnostic learning regime has outperformed the baseline when the hold-out trial site had been "NCI Urologic Oncology Branch", "Harvard ad MD Andersson", and "MSKCC". A case in point is when the "Harvard and MD Anderson" was the trial site. As far as, this repository has been formed by combining two different totally different trial sites, the domain shift is expectedly extra significant. ≈ 7 % when the hold-out repository was "Harvard and MD Anderson". We proposed an effective hospital-agnostic learning regime. The approach has been inspired by a DG approach, namely MASF, in which a DNN is trained by three loss capabilities in an episodic learning regime. These loss capabilities are cross-entropy used for hard class separation, triplet loss for comfortable class separation, and the KL divergence for hospital alignment. By leveraging this learning regime, a hospital-agnostic mannequin was trained, and its effectiveness in achieving a discriminative latent space representation and classification of RCC subtypes had been demonstrated and analyzed utilizing low-dimensional embedding visualization and classification accuracy in comparison to conventional supervised learning. Acknowledgment Images are from TCGA repository.

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